Crusted scabies in patients with recessive dystrophic epidermolysis bullosa
DOI:
https://doi.org/10.25251/fg7xcj97Keywords:
crusted scabies, epidermolysis bullosa, neglected tropical diseaseAbstract
Crusted scabies is a severe and highly contagious variant of scabies, characterized by extensive infestation of Sarcoptes scabiei var. hominis within the epidermis. It typically occurs in individuals with compromised immune responses to parasitic infections. Crusted scabies in patients with epidermolysis bullosa, particularly recessive dystrophic epidermolysis bullosa (RDEB), is rarely reported. Here, we describe a 14-year-old girl with severe RDEB who developed crusted scabies. Treatment with a combination of ivermectin and losartan led to significant clinical improvement.
References
1. Niode NJ, Adji A, Gazpers S, et al. Crusted scabies, a neglected tropical disease: Case series and literature review. Infect Dis Rep. 2022;14:479-491. doi:10.3390/idr14030051. PMID:35735761
2. Binić I, Janković A, Jovanović D, Ljubenović M. Crusted (Norwegian) scabies following systemic and topical corticosteroid therapy. J Korean Med Sci. 2010;25:188-191. doi:10.3346/jkms.2010.25.1.188. PMID:20052371
3. Manjunath S, Mahajan R, De D, et al. The severity of malnutrition in children with epidermolysis bullosa correlates with disease severity. Sci Rep. 2021;11:16827. doi:10.1038/s41598-021-96354-z. PMID:34413404
4. McCann K, Wiss K, Covington J, Laffert V, Gosselin KB. A case of recessive dystrophic epidermolysis bullosa associated colitis. JPGN Rep. 2023;4:e313. doi:10.1097/PG9.0000000000000313. PMID:37200727
5. Fuentes I, Yubero MJ, Morandé P, et al. Longitudinal study of wound healing status and bacterial colonisation of Staphylococcus aureus and Corynebacterium diphtheriae in epidermolysis bullosa patients. Int Wound J. 2023;20:774-783. doi:10.1111/iwj.13922. PMID:36787273
6. Zidorio AP, Dutra ES, Leão DO, Costa IM. Nutritional aspects of children and adolescents with epidermolysis bullosa: Literature review. A Bras Dermatol. 2015;90:217-223. doi:10.1590/abd1806-4841.20153206. PMID:25830992
7. Torrelo A, Zambrano A. Crusted scabies in a girl with epidermolysis bullosa simplex. Br J Dermatol. 2000;142:197-198. doi:10.1046/j.1365-2133.2000.03281.x. PMID:10819560
8. Lokuge B, Kopczynski A, Woltmann A, et al. Crusted scabies in remote Australia, a new way forward: Lessons and outcomes from the East Arnhem scabies control program. Med J Aust. 2014;200:644-648. doi:10.5694/mja14.00172. PMID:24938345
9. Bansal A, Mahajan V, Sharma N, et al. Epidermolysis bullosa pruriginosa: Report of a rare case. Internet J Dermatol. 2007;6:9943.
10. Martin D. CDC Yellow Book 2024. Accessed February 28, 2025. https://wwwnc.cdc.gov/travel/yellowbook/2024/infections-diseases/scabies
11. Nyström A, Thriene K, Mittapalli V, et al. Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms. EMBO Mol Med. 2015;7:1211-1228. doi:10.15252/emmm.201505061. PMID:26194911
12. Pourani MR, Vahidnezhad H, Mansouri P, et al. Losartan treatment improves recessive dystrophic epidermolysis bullosa: A case series. Dermatol Ther. 2022;35:e15515. doi:10.1111/dth.15515. PMID:35420725
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Copyright (c) 2026 Hanan Ashrafi Noviandari, Tuntas Rayinda, Maulidina Agustin, Joko Santosa, Arief Budiyanto, Retno Danarti (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
