Cutaneous metastasis of high-grade serous adenocarcinoma secondary to a gynecological malignancy
DOI:
https://doi.org/10.5070/0bz3fk76Keywords:
adenocarcinoma, cutaneous, Dermatopathology, Endometrial, Fallopian, Gynecology, immunohistochemistry, Oncology, OvarianAbstract
Cutaneous metastases from malignancies of gynecological origin are rare but have been described over the vulvovaginal area in the setting of ovarian, endometrial, and fallopian tube neoplasia. We present an 89-year-old woman with multiple non-tender, fleshy, skin-colored nodules with central ulceration and bleeding over the mons pubis. Skin biopsy and immunohistochemistry of these tumors were in keeping with metastatic high-grade serous adenocarcinoma secondary to a gynecological malignancy. This brief report aims to raise physician awareness about this rare skin presentation, which is unfortunately associated with a poor prognosis.
Downloads
References
1. Cheng H, Gao C, Zhang R, Yang Z, Zhang G. Two independent incidences of skin metastases in the umbilicus and abdominal wall in ovarian serous adenocarcinoma: A case report and review of the literature. Medicine. 2017 Dec;96(49):e9118. [PMID: 29245346].
2. Niebel D, Kranert P, Berneburg M, Drexler K, von Eichborn MI, et al. Indurated erythema of abdominal skin: An unusual presentation of metastatic endometrial carcinoma—Case report with literature review. Skin Health Dis. 2023 Apr;3(2):e136. [PMID: 37013123].
3. Otsuka I, Matsuura T. Skin metastases in epithelial ovarian and fallopian tube carcinoma. Medicine. 2017;96(33):e7798. [PMID: 28816970].
4. Kirshtein B, Meirovitz M, Okon E, Piura B. Sister Mary Joseph’s nodule as the first presenting sign of primary fallopian tube adenocarcinoma. J Minim Invasive Gynecol. 2006;13(3):234-236. [PMID: 16698532].
5. Galvan VG. Sister Mary Joseph's nodule. Ann Intern Med. 1998;128(5):410. [PMID: 9490607].
6. António AM, Alves JV, Goulão J, Bártolo E. Ovarian carcinoma presenting as cutaneous nasal metastasis. An Bras Dermatol. 2016 Sep;91:1014. doi: 10.1590/abd1806-4841.20165024. [PMID: 28300910].
7. Nie X, Chen X, Jiang Y, Zhong Y, Chen T, et al. Sister Mary Joseph nodule as cutaneous manifestations of metastatic ovarian cancer: A case report and review of the literature. Medicine. 2022;101(6):e28712. [PMID: 35147092].
8. Kuhn E, Ayhan A. Diagnostic immunohistochemistry in gynaecological neoplasia: A brief survey of the most common scenarios. J Clin Pathol. 2018 Feb 1;71(2):98-109. [PMID: 29183921].
9. Cheng B, Lu W, Xiaoyun W, YaXia C, Xie X. Extra-abdominal metastases from epithelial ovarian carcinoma: an analysis of 20 cases. Int J Gynecol Cancer. 2009 Apr 1;19(4). [PMID: 19509558].
10. Cormio G, Rossi C, Cazzolla A, Resta L, Loverro G, et al. Distant metastases in ovarian carcinoma. Int J Gynecol Cancer. 2003;13(2). [PMID: 12657111].
11. Bashline B, Danowski K, Ghaferi J, LaFond A. Cutaneous metastasis of endometrial carcinoma: an unusual and dramatic presentation. Cutis. 2019;103(4):217-218. [PMID: 31116808].
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Stephanie Farrugia, David Pisani, Michael J Boffa, Godfrey Baldacchino (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
