Dermoscopy and trichoscopy in Klippel-Trénaunay syndrome
DOI:
https://doi.org/10.25251/55hfj387Keywords:
dermoscopy, hypertrophy, Klippel-Trénaunay syndrome, vascular malformationsAbstract
Klippel-Trénaunay syndrome (KTS) is a slow-flow vascular malformation characterized by the triad of capillary malformation, limb hypertrophy, and venous malformation, with or without lymphatic malformation. Diagnosis requires the presence of at least 2 of these 3 clinical features; however, there is no consensus regarding dermoscopic or trichoscopic findings. We present the case of a 54-year-old woman with a history of congenital arteriovenous malformation who exhibited clinical, histopathologic, dermoscopic, and trichoscopic findings suggestive of KTS associated with a lower right limb ulcer. We describe a case of KTS diagnosed in adulthood and highlights the potential use of adjunctive diagnostic tools, including trichoscopy and dermoscopy.
References
1. Hughes M, Hao M, Luu M. PIK3CA vascular overgrowth syndromes: an update. Curr Opin Pediatr. 2020;32:539-546. doi:10.1097/MOP.000000000000009
2. Suda T, Katagiri A, Fujii H. Klippel-Trenaunay syndrome. Intern Med. 2023;62:1377-1378. doi:10.2169/internalmedicine.0251-22. PMID:36171122
3. Asghar F, Aqeel R, Farooque U, Haq A, Taimur M.Presentation and management of Klippel-Trenaunay syndrome: a review of available data. Cureus. 2020;12:e8023. doi:10.7759/cureus.8023. PMID:32528762
4. Pavone P, Marino L, Cacciaguerra G, et al. Klippel-Trenaunay syndrome, segmental/focal overgrowth malformations: a review. Children (Basel). 2023;10:1421. doi:10.3390/children10081421. PMID:37628420
5. Estrada M, Guadalupe ML, Enriquez R, De la Cruz J. Síndrome de Klippel-Trenaunay. Hallazgos clínicos y de imagen. An Radiol Mex. 2006;3:245-251.
6. Viswan P, Behera B, Sethy M, et al. Dermoscopic analysis of vascular malformations and tumors based upon dominant vascular dermoscopic features: a retrospective analysis from a tertiary care center of East India. Cureus. 2022;14:e26292. doi:10.7759/cureus.26292
7. Hassanandani T, Panda M, Agarwal A. Dermoscopy of Klippel-Trenaunay syndrome in a 6-month-old infant. Indian Dermatol Online J. 2021;13:824-825. doi:10.4103/idoj.IDOJ_607_20. PMID:36386749
8. Liu L, Sun J, Pan Y, Jiang X. A rare case of phakomatosis pigmentovascularis type IIb associated with inverse Klippel-Trenaunay syndrome and Sturge-Weber syndrome. Indian J Dermatol Venereol Leprol. 2019;85:618-620. doi:10.4103/ijdvl.IJDVL_55_19. PMID:31571612
9. Hammill AM, Wentzel M, Gupta A, et al. Sirolimus for the treatment of complicated vascular anomalies in children. Pediatr Blood Cancer. 2011;57:1018-1024. doi:10.1002/pbc.23124
10. Yuan F, Bailey CR, Khalil A, Weiss CR. Emerging role of sirolimus in the treatment of diffuse venous malformation in a woman with Klippel-Trenaunay syndrome. Cardiovasc Intervent Radiol. 2021;44:1672-1674. doi:10.1007/s00270-021-02902-5. PMID:34231008
11. Adams DM, Trenor CC 3rd, Hammill AM, et al. Efficacy and safety of sirolimus in the treatment of complicated vascular anomalies. Pediatrics. 2016;137:e20153257. doi:10.1542/peds.2015-3257. PMID:26783326
Downloads
Published
Data Availability Statement
The data supporting the findings of this case report are available from the corresponding author upon reasonable request. No datasets were generated or analyzed during the current study.
Issue
Section
License
Copyright (c) 2026 Mariana Orduz Robeldo, María José Giraldo Parra, Stephany Arias Linthon, Mariana Estrada Villamizar, Adriana Motta, Mariam Rolon (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
