Facial rejuvenation with autologous exosomes released from preconditioned platelet-rich plasma using the MCT system: A pilot study
DOI:
https://doi.org/10.25251/b5kf0v44Keywords:
exosomes, face rejuvenation, photothermal biomodulation, platelet-rich plasma, skin agingAbstract
Background: Safe, non-invasive, or minimally invasive techniques are available for facial rejuvenation, and recent research on exosomes has revealed promising avenues for new treatment options. The pilot study objective was to assess the efficacy of a facial rejuvenation treatment with autologous exosomes released from preconditioned platelet-rich plasma with the MCT System.
Methods: A prospective, single-center, randomized, controlled pilot study was conducted on patients with facial aging signs who received three sessions of autologous exosomes obtained using the MCT System. Results were assessed by measuring the subepidermal low-echogenic band using ultrasonography, taking photographs with a compact stereophotogrammetric 3D imaging system, and obtaining patients' feedback on skin aspect and improvement in appearance.
Results: Eleven patients (100% women) with a mean age of 57 (SD 4.1, range 51-65) were recruited; nine (81.8%) completed the study. Ultrasonographic measurements one month after the last treatment showed a mean percentage reduction in the subepidermal low-echogenic band thickness of 61.4% in the cheekbone and 39.35% in the cheek. Regarding patients’ perception, 77.8% reported skin improvement.
Conclusions: Treatment with autologous exosomes obtained using the MCT System was well tolerated and yielded substantial results in facial rejuvenation, reducing the subepidermal low-echogenic band and enhancing patients' perceived skin appearance.
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The data that support the findings of this study are available from the corresponding author, Laura Cordero, upon reasonable request.
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Copyright (c) 2026 Delia Vilà Rodríguez, Laura Cordero, Hernán Pinto (Author)
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