Aquagenic wrinkling of the palms in a healthy adolescent
DOI:
https://doi.org/10.25251/cvgw0d47Keywords:
pediatrics, skin diseases, rare diseasesAbstract
Aquagenic wrinkling of the palms (AWP) is a rare dermatologic condition characterized by rapid wrinkling, edema, and papules on the palms after brief water exposure. It is commonly associated with cystic fibrosis (CF) or CF carrier status but can also occur in individuals without these conditions. We report a healthy 12-year-old girl who presented with AWP without a family history of CF or related symptoms. After 4 minutes of water immersion, she exhibited typical wrinkling and translucent papules on the palms, which resolved completely within 15 minutes. A sweat test for CF was negative. The patient was managed with moisturizers and advised to minimize prolonged water exposure. This case highlights AWP as a potential early marker for CF or carrier status, even in the absence of other symptoms. Recognition of AWP may guide genetic screening and early intervention, underscoring the role of dermatologists in identifying this condition and facilitating timely diagnosis and management of CF.
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Copyright (c) 2026 César Bimbi, Amanda Nichele, João Pedro Locatelli Cezar, Camila Machado, André Anjos da Silva (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
