A review of the indications, safety, and efficacy of deucravacitinib: An expert consensus panel

Authors

  • Milaan Shah Department of Dermatology, Medical University of South Carolina, Charleston, SC Author
  • Lauren DeBusk Department of Dermatology, University of Texas Southwestern, Dallas, TX Author
  • M. Hunter Bohman Department of Internal Medicine, University of Louisville School of Medicine, Louisville, KY Author
  • Angela Rosenberg Department of Dermatology, University of Texas Southwestern, Dallas, TX Author
  • Joshua Burshtein Department of Dermatology, University of Illinois Chicago, Chicago, IL Author
  • Danny Zakria Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY Author
  • April Armstrong Department of Dermatology, University of California Los Angeles, Los Angeles, CA Author
  • Erin Boh Department of Dermatology, Tulane School of Medicine, New Orleans, LA Author
  • Alice Gottlieb Department of Dermatology, University of Texas Southwestern, Dallas, TX Author
  • Saakshi Khattri Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY Author
  • Graham Litchman Touro University Nevada College of Osteopathic Medicine, Las Vegas, NV , Vivida Dermatology, Las Vegas, NV Author
  • Joseph Merola Department of Dermatology, University of Texas Southwestern, Dallas, TX , Department of Medicine, Division of Rheumatology, UT Southwestern Medical Center and O’Donnell School of Public Health, Dallas, TX Author
  • Andrea Murina Department of Dermatology, Tulane School of Medicine, New Orleans, LA Author
  • Mark Lebwohl Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY Author

DOI:

https://doi.org/10.25251/ymnfwz12

Keywords:

deucravacitinib, lupus, cutaneous lupus, effeicacy, safety, psoriasis, psoriatic arthritis, malignancy

Abstract

Background: Deucravacitinib is a novel, allosteric, selective TYK2 inhibitor FDA-approved for the treatment of moderate-to-severe plaque psoriasis in adults. Deucravacitinib is under investigation in numerous clinical trials to establish its efficacy and safety for other indications. Thus, this expert consensus panel was assembled to provide clinical guidance on the applications of and clinical considerations for deucravacitinib.

Methods: A comprehensive literature search of PubMed, Scopus, and Google Scholar was completed for English-language original research articles regarding deucravacitinib. An expert panel of eight dermatologists reviewed the literature and developed consensus statements regarding the additional indications, safety, and efficacy of deucravacitinib. Using a modified Delphi process, each statement had supermajority approval and was designated a strength of recommendation based on the Strength of Recommendation Taxonomy criteria.

Results: The literature search resulted in 250 articles regarding deucravacitinib. 43 relevant articles were included and distributed to the panelists for review prior to the roundtable discussion. The panel unanimously voted to adopt 14 consensus statements and recommendations: 11 were a strength of “A”, 1 was a strength of “B”, and two were a strength of “C”.

Conclusion: Deucravacitinib is an established treatment for plaque psoriasis that has shown strong evidence supporting safety and efficacy for psoriatic arthritis, cutaneous lupus, and systemic lupus erythematosus. The 14 consensus statements created by the panel provide expert recommendations regarding the efficacy, safety, and additional potential indications for deucravacitinib. Additionally, the expert panel notes that deucravacitinib is generally safe, as it can be safely combined with conventional synthetic DMARDs, immunosuppressants, and biologics and currently does not have data that support elevated malignancy risk, tuberculosis reactivation, increased risk for herpes zoster, or associated laboratory abnormalities. The expert panel concludes that deucravacitinib is an exciting medication that will likely have a larger role in the treatment of various conditions in the future.

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05/09/2026

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Consensus Statements and Recommendations